With a V-8, there's a cylinder firing every 90 degrees of crankshaft rotation - each cylinder fires once for every two revolutions of the crankshaft; with a V-12, there's a cylinder firing every 60 degrees of crankshaft rotation. The closer together those firing impulses are per each revolution, the smoother the engine is.
One of the limitations of an internal combustion engine is piston speed (moving up and down in the cylinder) in feet per minute and its effect on component strength and reliability (connecting rods and wrist pins); the theoretical maximum is 4,000 feet per minute, and things get pretty tricky above 3,000 feet per minute. The more cylinders you have, the fewer feet per minute each piston has to move at peak power.
There aren't many single-cylinder engines (except for small ones like lawn mowers); the only example I can think of right now for an engine with few cylinders and huge displacement is old John Deere tractors, which had a 2-cylinder engine, a HUGE iron flywheel to damp out the firing pulses (one per revolution), and only ran at about 800 rpm.
Engine design is a lot of trade-offs for intended use (power vs. torque), physical size and weight, engine compartment packaging, fuel efficiency, emission controls, durability and reliability requirements, serviceability, part count/complexity, material selection, cost, tooling investment, manufacturing technology available, etc., etc. - nothing simple about it, especially when the investment for a new engine is over a billion dollars (automatic transmissions are even more).
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