The only big advantage of silicone is that it won't absorb water, like glycol will.
If you don't drive often (ie, the car sits for long periods of time), this can be an advantage.
In normal use, glycol is better. It is "stiffer," as pws69 says, and you won't have compatibility problems. If you don't completely flush all of your existing fluid out before adding silicone, the two will turn to glue wherever they mix.
So, if you really want to switch to silicone, you need to not only drain the system, but flush it with a flushing solvent.
I would say that there isn't much difference between the two, but the hassle of switching makes it easier and safer to stick with standard fluid.
Plus, if you ever need to top off the fluid somewhere, and there isn't silicone available (many places don't carry it), you're stuck.
Joe