It's your car and your money, so have a blast and do what your heart desires.
IMHO I don't think that you are gonna have a super economy car there by putting a V-6 in there. If you use a 4.3 which is one of the best V-6 chevy made, you are still looking at a bore and stroke that is the exact same as a 5.7, just minus 2 cylinders. Small engine pushing a big car is not going to give you that much of a gain without other mods. Who knows how much it is gonna cost to do a full conversion and make it run right.
I would think you would have better results, if you are looking for a gain in gas mileage and money savings by swapping in a 5.0 TPI/TBI out of an fbody. Smaller bore cylinder to deal with fuel consumption, plus most everything off of your current engine will swap right over, some might take a little coaxing to fit. Put a tall gear like a 2.73 in the back and im sure it will get better mileage than the 5.7 TPI.
Just my thoughts, have a blast with whatever you deceide.