It is possible, depending on your engine's camshaft profile and cylinder head choice, that a 750 DP might work ok. On the other hand, if you have a mild cam and relatively stock heads, a 750DP is too much and needs to be replaced with a vacuum secondary 650 or 700.
Typically, Holley DPs run rich out of the box. They can be recalibrated such that they run pretty well on the street, but, admittedly, the job is more than just changing jets.
"Auto Enthusiast" magazine published a 2-part series late last year on just that subject...tuning Holley double pumpers for street use. Look in the magazine's web site. It may have previously-published articles on-line.