As Mic said---UR injectors are too big
Steve-
Pardon me for jumping in.
Using the formula in the above link, my 406, at about 550hp, uses 30pph Bosch injectors at 47psi. Opinions among experts vary as to using higher pressure and smaller injectors, or vice versa. Low vacuum, read by a MAP sensor, will signals the ECM of a more open throttle than actually exists, hence it demand more fuel, producing a run rich condition. Associated with all of this is black/fouled plugs, popping, as the unburned fuel explodes in the exhaust, black exhaust, etc.
Once the injectors are properly sized, fuel pressure and ECM pulses must be adjusted for proper A/F ratio. While there is some 'art' to this, the best way is to to judge how radical the changes were. Fuel pressure, while certainly essential to proper tune, is only part of the equation and is limited, high and low, by proper spray patterns and such.
The ECM's block learn capability is limited, but reading these adjustments to the fuel tables (+/-128 max), as it tries to optimize the burn, tells the full story. Too low vacuum can easliy exceed how lean the ECM can adjust, as I saw on my slightly modified, Crossfired, L83 and again on this port injected 406. The fairly radical, hydraulic roller camshaft on this 406 demanded new programming of my ECM's chip, in both advance and fuel delivery.
Once fuel pressure is set, a rather 'gross' and broadband adjustment, proper programming of your ECM will be the only right way to get the proper mixture under all driving conditions. Further adjustment of pressure after the ECM is dialed in, will cause the ECM to try, again, to optimized it.
Ignition components, such as a multi spark discharge box can burn more fuel, but also mask problems in the fuel area and those with failing wires or plugs. The stock system, properly maintained, will deliver more than adequate spark, unless one boosts the intake charge with a blower or exceeds 7000 rpm or so.
Mic is right again to suggest going back to the 24# sprayers. You might consider returning to the stock TB, too, unless you turns such high revs as to need all that air. A 52mm BBK serves this 406 well, up to redline.
I submit that your CAT is working very hard in cleaning up your exhaust, but cannot do so until totally warmed up, as your drive to the loop suggests.
Probably not what you want to hear, but the truth, as best I know it.

Mike