I'm no expert, but I'll let you know what I know. When refering to 2 or 4 bolt mains, they are refering to the caps that hold the crank shaft in place on the engine block. As horsepower is increased, the thrust on the crank shaft can be tremendous and more bolts are needed to keep the crank from comming loose from the block.
The rear end bolt counts are a little more confusing, but a typical GM rear end for a 1/2 ton truck usually is a 10 bolt. It is the number of bolts on the housing holding the cover in place. The 3/4 ton truck get a 12 bolt differential. Usually becuase the rear end is larger to be more durable there is a need for more bolts to hold the cover in place. In this case the number of bolts coincidentally mean more strength, but the bolts have nothing directly related to that fact. Ford has a 9 bolt rear end that is supposidly very strong and it matters on what years, etc you are talking about as far as durability. Being a GM guy, I don't keep up on the Ford stats all that much. If anybody else has some corrections to my opininion, please educate me, I'm always willing to learn. - Ron