A stock LT4, when it comes to the valve train, is a different animal. It uses what GM calls NET BUILD, which means there is NO adjustable lifter preload without changing the length of the pushrod. All you do is torque down the adjusting nuts, IIRC 18 lb/ft) and you're done.
For LT1s and earlier engines, it's more complicated, calling for finding Zero lash then setting the lifter reload by turning the adjusting nuts a certain amount. In this procedure, finding Zero lash is particularly critical.
So, after changing the cam, and if you're continuing to use the stock NET BUILD setup, you need to verify that the pushrod length is correct so as to correctly preload the lifters. If you're now using an adjustable valve train, then you need to set each lifter individually using the most often recommended Intake Closing/Exhaust Opening (IC/EO) procedure.
Too little lifter preload can cause a noisy valve train; too much and one (or more) valves can be held open causing the engine not to run well, if at all.
Keep us posted.
Jake