The E3 plug is relatively new to the market. I don't think there is much collective experience with that product.
Personally, I've never used them and never would.
The spark plug market is a place where snake oil and smoke & mirrors abound. For some reason, many people loose common sense when they look at those cylindrical white and silver devices.
"Fire Injector", "Split Fire", "E3", "Platinum Plus 4" and so forth...all marketing–some of it damn good marketing and some of it not so good. The ones not marketed well either become sales failures or end up in court.
My advice with spark plugs is stick to proven technology and look at what OE manufacturers use...I don't mean you must use OE replacement plugs–I'm talking about what general technology OE's use.
Back in the early '00s, GM was on the forefront of the move from double-platinum-tipped plugs to iridium tipped plugs and, initially, Denso was the supplier of those and it may still supply GM, now. They first showed up on Corvette about 02 or 03, as I remember.
About the same time, seeing what GM was doing, I researched Denso's aftermarket performance spark plug which uses some of that technology developed by OEs. Part of my study was reading an SAE Paper on Iridium tipped plugs which Denso engineers published about that time. As a result of my research, I tried Denso Iridium Power plugs in one of my Vettes. Now I have them in all my vehicles. The plug life has been oustanding...I've seen 50,000+ miles in a street high-performance duty cycle but I've not run them longer than that. I figure at 50K, I'll change them on GP. Plug performance has been excellent.
Since then, many of the major plug makers have brought out their own version of an iridium tipped plug.
E3?
Not.
I'll stick to my Densos. I use the IT20 in my C5, my 99 Blazer and my 02 Camaro. I use the IT22 in my 95 ZR-1. I use the ITF20 in my 71 Coupe and the IVT20 in my HHR. You'll note all those are one heat range colder than Denso's catalog recommendation and that's standard procedure for my cars which get run hard at times.