Most those "lot of 650hp LS6s out there running supercharges and stock bottom ends" are in a reality distortion field of some kind. I'd like to see a 650hp blown Gen 3 with stock pistons last very long. I'll admit that 650 is possible that way, but not for long and certainly not long at 7200 rpm.
The 500hp LS6 discussed here is, perhaps a bit optimistic, but it could be done (and 475 is certainly doable) with AFR heads, the FAST intake manifold, slightly larger injectors (maybe) low restriction intake, bigger TB (maybe), the right camshaft and valve train, 1.8 rockers, headers, no cats, low restriction exhaust and proper calibration. I think such an engine would marginally durable if the rev limit was 6800 rather than 7200.