Not on a C6 with auto.
I did cover the installation and testing of a Flowmaster exhaust on a C6 manual a couple years ago for an article in "Corvette Enthusiast" magazine. The installation was fairly easy for the DIY, provided you can get the car up on jack stands to do the work.
The sound was typically Flowmaster but perhaps just a little more subdued at high rpm than some people shopping aftermarket exhausts would like, but for me it was just right. If I had a C6, that'd be the exhaust I'd buy.
I have Flowmaster exhausts on my C3, my C4, my Camaro and my old Malibu. My Wife, the Fairest Sandra the Red, has one on her 82 CE and her HHR. On my C5, I kept the stock exhaust because it's titanium from the rear axle back--I prefer the lighter weight and it sounds good as is. If my C5 was not a Z06, I'd have put a Flowmaster exhaust on that car, too.
Above all else, the reasons I like Flowmaster are 1) the sound and 2) that Flowmaster exhausts are typically a pretty good value.